Lindane was used in Mexico as a pesticide in agriculture and in pharmaceuticals for both humans and animals. Its use led to accumulation in humans and other organisms. In order to address this problem, Mexico developed a national profile that provided a summary of the use of lindane in Mexico, and availability and cost of alternatives. The compilation of the data was done through a coordinated and collaborative effort with multi-stakeholder participation. The evidence assembled in the profile helped the government decide to revoke the registration for all uses of lindane, including a phase-out for pharmaceutical uses. This experience also led Mexico to support the nomination of lindane and related compounds as candidates for substances to be controlled under the Stockholm Convention on Persistent Organic Pollutants (POPs).