Malaria is a transboundary problem affecting most tropical countries. In Central American and Mexico, the main malaria vectors are A. Pseudopunctipenis, A. Albimanus, A. darlingi and A. Vestitipenis. It is estimated that 89,128,000 people in Mesoamerica live in areas environmentally suitable for the transmission of malaria, of which 23,445,000 (35%) live in highly endemic areas. Migration of infected people and environmental conditions such as rainfall patterns, altitude and temperature all facilitate the movement of the disease across national borders. Only an integrated regional approach can address the human and environmental challenges in malaria prone areas.