In Zambia, indoor residual spraying and insecticide treated bed netsare deployed for malaria vector control. The supplementation of these interventions with Larval Source Management has enhanced their efficacy by suppressing the abundance of vectors, particularly in urban areas. The mean densities of larvae reduced from 45 per 250 ml in 2003 to 1.2 in 2010 and that of adults reduced from 1.7 per room in 2003 to zero in 2010 in urban areas. In rural areas, an average of 9.7 adult Anopheles mosquitoes was demonstrated. Malaria prevalence reduced from 25.3% to less than 1% and was suppressed at the same level with Larval Source Management. This has enhanced the acceptability of other vector control interventions by communities. Larval Source Management has been successfully integrated as a complementary tool and an indispensable resistance management strategy for the malaria control programme. However, insecticide resistance surveillance and determination of underlying mechanisms is essential for rational resistance management. Country-specific guidelines and information, communication and education materials are critical to facilitate objective deployment of interventions and enhance community participation.